منابع مشابه
β-Adrenoceptor subtypes and cAMP role in adrenaline- and noradrenaline-induced relaxation in the rat thoracic aorta
Object We identified the β-adrenoceptor (β-AR) subtypes responsible for the relaxant responses to adrenaline (AD) and noradrenaline (NA) in the rat thoracic aorta and examined the role of cAMP which is involved in these relaxant responses. Methods The effects of β-AR antagonists or the adenylyl cyclase inhibitor SQ 22,536 on AD- and NA-induced relaxant responses in phenylephrine-induced contrac...
متن کاملFunctional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.
PURPOSE To identify the α(1)-adrenoceptor (α(1)-AR) subtypes mediating vascular adrenergic responses in murine ophthalmic arteries. METHODS Expression of mRNA was quantified for individual α(1)-AR subtypes in murine ophthalmic arteries using real-time PCR. To assess the functional relevance of α(1)-ARs for mediating vascular responses, ophthalmic arteries from mice deficient in one of the thr...
متن کاملSubmandibular Gland Acinar Cells Express Multiple 1-Adrenoceptor Subtypes
We evaluated an acinar cell line (SMG-C10) cloned from rat submandibular glands as a possible model for 1-adrenoceptor regulation of submandibular function. 1-Adrenoceptors are subdivided into three subtypes called 1A, 1B, and 1D, which can be distinguished from one another by their differential affinity values for subtype-selective 1-adrenoceptor antagonists. Thus, 1-adrenoceptor subtypes in S...
متن کاملAtypical -Adrenoceptor Subtypes Mediate Relaxations of Rabbit Corpus Cavernosum
This study was performed to characterize the -adrenoceptor population in rabbit isolated corpus cavernosum (RbCC) by using nonselective and selective -adrenoceptor agonists and antagonists in functional assays. Metaproterenol, ritodrine, fenoterol, and 8-hydroxy-5-[(1R)-1-hydroxy-2-[N-[(1R)-2-( -methoxyphenyl)-1-methylethyl]amino]ethyl]carbostyril (TA 2005) (3–100 nmol each) dose dependently re...
متن کاملEffects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes.
We have investigated the affinity and selectivity of tamsulosin and its metabolites, M1, M2, M3, M4 and AM1, at the tissue and the cloned alpha-1 adrenoceptor subtypes in the radioligand binding and the functional studies. In the radioligand binding studies, the compounds competed for [3H]prazosin binding to the rat liver and kidney alpha-1 adrenoceptors, with the rank order of potency tamsulos...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36389-9